Guangxin Liang

Date:2020-06-19Views:6834设置

梁广鑫课题组介绍


课题组长
广鑫,终身副教授、研究员

办公室:物质学院3号楼510-2     实验室:物质学院3号楼501

电子邮件:lianggx@shanghaitech.edu.cn 

个人简历

20201-至今 终身副教授 上海科技大学物质与科学学院

20099-20201 教授 南开大学化学学院/元素有机化学国家重点实验室

20093-20099月 教授 南开大学药学院

20076-20093月 高级研究员 美国雅培公司全球药物研发中心制药工艺部

20028-20075月 博士研究生 美国加州大学伯克利分校化学学院

20008-20026月 硕士研究生 美国俄亥俄州立大学化学与生物化学系

19978-19995月 硕士研究生 南开大学化学系

19938-19976   本科生   南开大学化学系





研究介绍


  


1)    具有重要生物活性或生理功能的复杂天然产物的全合成

2)  药物及精细化学品的合成工艺研究

课题组目前完成的天然产物分子:

  


本课题组长期诚聘博士后研究员,研究助理,硕博连读研究生及联合培养研究生。有意申请者请直接与课题组长联系。




发表文章

1)      Qiao, T.; Wang, Y.; Zheng, S.; Kang, H.; Liang, G.* “Total Syntheses of Norrisolide-Type Spongian Diterpenes Cheloviolene C, Seconorrisolide B, and Seconorrisolide C” Angew. Chem. Int. Ed. 2020, asap. (DOI: 10.1002/anie.202005600)

  


2)      Sun, P.; Zhang, C.; Qiao, T.; Ao, J.; Wu, S.; Liang, G.* “Stereoselective Construction of the Highly Congested Tricyclic Core Structure in Leucosceptroid H” Org. Lett. 2020, asap. (DOI: 10.1021/acs.orglett.0c01672)

  


3)      Dong, C.; Qiao, T.; Xie, Y.; Zhang, X.; Ao, J.; Liang, G.* “Rapid Construction of the ABD Tricyclic Skeleton in Meliacarpinin B from Carvone Enabled by an INOC Strategy” Org. Chem. Front.2020, asap. (DOI: 10.1039/D0QO00576B)

  

 


4)      Li, X.; Liang, G.*; Shi, Z.* “Regio-Divergent C-H Alkynylation with Janus Directing Strategy via Ir(III) Catalysis”Chin. J. Chem. 2020, 38929.



5)      Hu, N.; Dong, C.; Zhang, C.; Liang, G.* “Total Synthesis of (–)-Indoxamycins A and B” Angew. Chem. Int. Ed. 2019,58, 6659.

  

 


6)      Zhang, X.; Zhang, C.; Wang, X.; Liang, G.* “Mild Friedel–Crafts Reactions Enable a Robust Synthesis of Roseophilin” Org. Lett.2019,21, 3357.

  

 


7)      Deng, M.; Yao, Y.; Li, X.; Li, N.; Zhang, X.; Liang, G.* “Rapid Construction of the ABCE Tetracyclic Tertiary Amine Skeleton in Daphenylline Enabled by an Amine–Borane Complexation Strategy” Org. Lett.2019,21, 3290.

  

 


8)      Deng, M.; Zhang, X.; Li, Z.; Chen, H.; Zang, S.; Liang, G.* “Rapid Construction of the Common [5–5–6] Tricyclic Ring Skeleton in Polycyclic Cembranoids and Nor-cembranoids via Intramolecular 1,3-Dipolar Cycloaddition” Org. Lett.2019,21, 1493.

  

 


9)      Bi, X.; Xu, W.; Yao, Y.; Zhou, Li.; Liang, G.* “Total Syntheses of a Family of Cadinane Sesquiterpenes” J. Org. Chem. 201883, 5825.

  

 


10)  Lv, Z.; Chen, B.; Zhang, C.; Liang, G.* “Total Syntheses of Trichorabdal A and Maoecrystal Z” Chem. Eur. J. 201824, 9773.

  

 


11)  Yao, Y.; Wang, X.; Liang, G.* Total Syntheses of (+)-Agelastatin A and (+)-Agelastatin B through Cationic CyclizationsTetrahedron201773, 4538.

  

 


12)  Geng, Q.; Xiao, X.; He, G.-R.; Yao, S.-M. Liang, G.* “One Stone Two Birds: Degradation of Persistent Organic Pollutants to a Valuable Industrial Chemical Production of Pentafluoropropionyl Fluoride from HFPO Oligomers Catalyzed by Cesium Fluoride in Tetraglyme” Chin. Chem. Lett.201627, 1009.

  

 


13)  Geng, Q.; Li, Z.; Lv, Z.; Liang, G.* “Progress in Total Syntheses of Leuconolam-Leuconoxine-Mersicarpine Alkaloids” Chin. J. Org. Chem.201636, 1447.

 

14)  Qiao, T.; Liang, G.* “Recent Advances in Terpenoid Syntheses from China” Sci. Chin. Chem. 201659, 1142.

 

15)  Li, Z.; Geng, Q.; Lv, Z.; Pritchett, B. P.; Baba, K.; Numajiri, Y.; Stoltz, B. M.*; Liang, G.* Selective Syntheses of Leuconolam, Leuconoxine, and Mersicarpine Alkaloids from a Common Intermediate through Regiocontrolled Cyclizations by Staudinger ReactionsOrg. Chem. Front. 2015, 2, 236.



16)  Zhou, L.; Yao, Y.; Xu, W.; Liang, G.* Total Syntheses of (±)-Omphadiol and (±)-Pyxidatol C through a Cis-Fused 5,7-Carbocyclic Common IntermediateJ. Org. Chem. 2014,79, 5345.

  

 


17)  Lv, Z.; Li, Z.; Liang, G.* Total Synthesis of Mersicarpine through a Cationic Cyclization ApproachOrg. Lett.2014,16, 1653.

  

 


18)  Xu, W.; Wu, S.; Zhou, L.; Liang, G.* Total Syntheses of EchinopinesOrg. Lett.2013, 15, 1978.

  


19)  Li, Z.; Liang, G.* “Quick Access to the Core of Mersicarpine through an SNAr Strategy” Tetrahedron Lett. 201354, 242.

  

 


20)  Zhan, F.; Liang, G.* Formation of Enehydrazine Intermediates through Coupling of Phenylhydrazines with Vinyl Halides: Entry into the Fischer Indole SynthesisAngew. Chem. Int. Ed. 2013,52, 1266.

  

 


21)  Yao, Y.; Liang, G.* Rapid Construction of the ABC Ring System in the Daphniphyllum Alkaloid Daphniyunnine COrg. Lett.2012,14, 5499.

  

 


22)  Zhang, X.; Mu, T.; Zhan, F.; Ma, L.; Liang, G.* “Total Synthesis of (–)-Isatisine AAngew. Chem. Int. Ed.2011,50, 6164.

  




本组成员

敖军礼


外访生:南开大学博士研究生

邮箱:aoj190@163.com

臧绍丽


外访生:南开大学硕士研究生

邮箱:shaolizang@163.com

刘潇蓬


外访生:南开大学本科生

   邮箱:1713636@mail.nankai.edu.cn

何鑫儿


暑期实习生/英国伯明翰大学本科毕业,秋季入学牛津大学研究生院

邮箱:XXH813@student.bham.ac.uk



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